Contrary to traditional medicine modalities such as disinfectants and antibiotics, Ozone is quite economical which will make a marked reduction in medical cost and invalidity. Dentistry is presently improving with the induction of modern science into practice. Ozone therapy has been more beneficial than present conventional therapeutic modalities which follow a minimally invasive and conservative application to dental treatment. The exposition of molecular mechanisms of ozone further benefits practical function in dentistry. Treating patients with ozone therapy lessens the treatment time with an immense deal of variation and it eradicates the bacterial count more specifically. The treatment is painless and increases the patients' tolerability and fulfillment with minimal adverse effects. Contraindication of this controversial method should never be forgotten.