Issleduyutsya osobennosti kontaminantnogo fona gorodskogo vozdukha v trekh razlichayushchikhsya ekologicheskikh rayonakh i ikh sezonnye kharakteristiki; razrabotan poetapnyy kliniko-epidemiologicheskiy podkhod k otsenke svyazey mezhdu revmaticheskoy bolezn'yu serdtsa (RBS) i zagryazneniyami vozdukha. Dany etiologicheskie i patogeneticheskie obosnovaniya revmatogennogo vliyaniya zagryazneniy na sostoyanie protivosteptokokkovogo i obshchego immunnogo, biokhimicheskogo i morfofunktsional'nogo statusa, vyyavlena ikh kliniko-gigienicheskaya kriterial'naya znachimost'. Opredeleny patogeneticheskie vzaimosvyazi v sisteme "okruzhayushchaya sreda - RBS" na populyatsionnom, organizmennom, tkanevom i organnom, kletochnom, subkletochnom i molekulyarnom urovnyakh.Razrabotany modeli zavisimosti nosoglotochnoy infektsii u bol'nykh ot urovnya zagryazneniy vozdukha, pozvolyayushchie prognozirovat' vozniknovenie ostroy revmaticheskoy likhoradki v svyazi s respiratornym vozdeystviem v sezonnom aspekte i uchityvayushchie effekt zapazdyvaniya. Predlagayutsya prakticheskie rekomendatsii dlya preduprezhdeniya zabolevaemosti.