Proper distribution of conditioned air in an air conditioning room is very important for comfort air conditioning to maintain the comfort parameters within a prescribed limit. Supply air outlets and return air locations affects the human comfort significantly by maintaining comfort parameters uniformly. Thus, the problem of finding the optimal arrangements of location of the supply air diffusers and return air outlets has been considered in this book. CFD through FLUENT is considered for analysis of the problem. Different arrangements of supply and return air points are considered for observing the comfort parameters like air temperature, air velocity, relative humidity in room air distribution so that the optimal arrangements can be evaluated where majority of the occupants present in the room feel comfortable. An experimental validation of the work is also performed to check the applicability of CFD in the analysis of room air distribution. This book will be helpful for the researchers using CFD as a tool for analysis of room air distribution with prototype experimentation validation so that the procedure can be applied to real life requirements.