Dr. Squires has served as principal investigator on research studies at the University of Oregon on the ASQ system. She is a professor in special education, focusing on early intervention and early childhood special education. She directs the Early Intervention Program and is associate director of the University of Oregon Center for Excellence in Developmental Disabilities.

Dr. Squires has directed national outreach training activities related to developmental screening and the involvement of parents in the assessment and monitoring of their child's development. She currently directs research grants related to early childhood mental health and systems change related to early identification and treatment of newborn infants exposed prenatally to drugs and alcohol. In addition to her interests in screening and early identification, Dr. Squires directs the doctoral and master's level early intervention/special education personnel preparation programs and teachers courses in early intervention/special education at the University of Oregon.