Aging of the Genome: The Dual Role of DNA in Life and Death
| AUTHOR | Vijg, Jan |
| PUBLISHER | OUP Oxford (03/29/2007) |
| PRODUCT TYPE | Paperback (Paperback) |
Description
Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its consequences. Vijg critically reviews the concept of genomic instability as a possible universal cause of aging in the context of a new, holistic understanding of genome functioning in complex organisms resulting from recent advances in functional genomics and systems biology. It provides an up-to-date synthesis of current research, as well as a look ahead to the design of strategies to retard or reverse the deleterious effects of aging. This is particularly important in a time when we are urgently trying to unravel the genetic component of aging-related diseases. Moreover, there is a growing public recognition of the imperative of understanding more about the underlying biology of aging, driven by continuing demographic change.
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Product Format
Product Details
ISBN-13:
9780198569237
ISBN-10:
0198569238
Binding:
Paperback or Softback (Trade Paperback (Us))
Content Language:
English
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Page Count:
384
Carton Quantity:
10
Product Dimensions:
7.40 x 0.80 x 9.60 inches
Weight:
1.90 pound(s)
Feature Codes:
Bibliography,
Index,
Table of Contents,
Glossary,
Illustrated
Country of Origin:
US
Subject Information
BISAC Categories
Science | Life Sciences - Genetics & Genomics
Science | Life Sciences - Molecular Biology
Dewey Decimal:
612.8
Library of Congress Control Number:
2006039672
Descriptions, Reviews, Etc.
publisher marketing
Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its consequences. Vijg critically reviews the concept of genomic instability as a possible universal cause of aging in the context of a new, holistic understanding of genome functioning in complex organisms resulting from recent advances in functional genomics and systems biology. It provides an up-to-date synthesis of current research, as well as a look ahead to the design of strategies to retard or reverse the deleterious effects of aging. This is particularly important in a time when we are urgently trying to unravel the genetic component of aging-related diseases. Moreover, there is a growing public recognition of the imperative of understanding more about the underlying biology of aging, driven by continuing demographic change.
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Author:
Vijg, Jan
Jan Vijg is Professor at the Buck Institute for Age Research in Novato, California, USA
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List Price $93.00
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